Three-wavelength spectrophotometric method has been developed for the simultaneous estimation of Tramadol Hydrochloride (TRA) and Diclofenac Sodium (DIC) in pharmaceutical preparations. The absorbance value at 288nm was used for the estimation of DIC where TRA showed zero absorbance. The absorbance value for TRA was estimated by taking difference of absorbance at two wavelengths 283 nm and 268.9 nm. These method obeyed Beer’s law in the concentration range of 4-24 μg/ml for TRA and 6-36 μg/ml for DIC in 0.1N NaOH. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method. The method was found to be simple, rapid and accurate. Hence can be used for routine simultaneous estimation of these drugs in formulations.
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